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Cardiovascular Disease National Collaborative Enterprise (CADENCE)

Data, Imaging and Tissue Repository

Explore how CADENCE's national repository brings together patient data, CVD images, and tissue to support research and improve heart care in Singapore.

Last updated on 8 July 2026

CADENCE's Data, Imaging & Tissue Repository Platform, with representation from the National Heart Centre Singapore, National University Heart Centre, Singapore, and Tan Tock Seng Hospital, in partnership with Bioinformatics Institute (A*STAR), IHiS, and the Ministry of Health, looks forward to bring together patient data, cardiovascular disease (CVD) images and tissue from across the clusters and institutions into a National Cardiovascular Data Repository that can updated in real-time.

Through this platform, we aim to:

  • Transform and integrate large unstructured datasets into a single "fit-for-purpose" structured dataset and linkage of these datasets to health outcomes

  • Serve as both a discovery and validation engine for academic and industry collaborators

  • Facilitate CVD research to improve health outcomes and clinical care of CVD patients in Singapore

By establishing this platform, all CVD research capabilities and resources established nationwide can be shared through a standardised governance process to ease access for CADENCE partners, researchers and industrial collaborators.

This national resource would greatly facilitate the translation of novel research and innovative discoveries into the clinical setting for patients.

The platform, in collaboration with sister unit SCRI, has also facilitated in the setup of the Singapore's Clinical Trials Portal (CTSG. (opens in new tab) is crafted to cater to patients, caregivers, clinical investigators and companies by making clinical trial information more accessible and comprehensible. By demystifying the clinical trial landscape, CTSG aims to encourage greater interest in clinical trials, fostering innovation and improving health outcomes.

Bold blue text reading PLATFORM LEADS on a light blue banner with faded hexagonal tech icons in the background.

Lead:

Prof Yeo Khung Keong, CEO of National Heart Centre Singapore, smiling in glasses and a suit.

Co-Lead:

A/Prof James Yip, Executive Director of National University Heart Centre, Singapore, wearing a suit and red tie.

Co-Lead:

Man in suit and blue tie beside text naming A/Prof Sebastian Maurer-Stroh, Executive Director, Bioinformatics Institute A*STAR

Co-Lead:

Dr Ho Hee Hwa, Senior Consultant and Head of Interventional Cardiology at Tan Tock Seng Hospital, wearing glasses.
Banner with bold blue text "USE CASE" over a light background with hexagonal medical technology icons.

Clinical and cost-effectiveness of treatments for patients with heart failure

Analyses of existing Asian heart failure cohorts have highlighted unique features of Asian heart failure patients when compared to HF patients in the USA and Europe.

These include earlier age of onset (~10 years), more aggressive disease with worse clinical outcomes, and unique heart failure clinical phenotypes (e.g., lean diabetic patients with heart failure with preserved ejection fraction).

Through this use case, CADENCE aims to:

  • Inform healthcare policies by influencing prescribing guidelines for heart failure patients

  • Provide the evidence base for national drug treatment guidelines for heart failure.

This use case is led by:

Prof Nicholas Graves, smiling man with glasses and gray hair, wearing a gray suit and blue tie, Duke-NUS Medical School.

Co-leads

Dr Raymond Wong, smiling man in dark suit and tie with glasses, Senior Consultant at National University Heart Centre Singapore.
A/P Sanjeewa Kularatna, Health Services and Systems Research, Duke-NUS Medical School, smiling man in navy shirt.
Dr Sameera Jayan Senanayake, smiling man with glasses and plaid shirt, Principal Research Scientist at Duke-NUS.
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